Helmholtz Center for Infection Research HZI | Germany
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🌟 BIOGRAPHY OF DR. LINA HERHAUS 🌟
Title: Trailblazer in Immune Signaling and Molecular Mechanisms 🌱🔬
🏫 EARLY ACADEMIC PURSUITS
Dr. Lina Herhaus’s journey into the world of science began during a transformative gap year in Mexico, where her exposure to research at ECOSUR ignited a fascination with genetics and molecular mechanisms. Driven by this passion, she pursued a degree in Molecular Biology, studying across Germany and the UK. She then advanced to complete her PhD at the MRC Protein Phosphorylation and Ubiquitylation Unit, where she honed her expertise in post-translational modifications.
👩🔬 PROFESSIONAL ENDEAVORS
Dr. Herhaus's career reflects a dedication to pushing the boundaries of molecular and immune research. After earning her PhD, she joined Professor Ivan Dikic’s lab in Frankfurt as an EMBO Long-Term Fellow, expanding her knowledge of cellular signaling and immunity. In 2020, she embarked on her independent research journey, founding the "Immune Signaling" group at Goethe University. Currently, she leads the Microbial Stargazing Program at HZI and serves as a W1 Professor at Hannover Medical School.
Dr. Herhaus's lab explores:
- Protein Homeostasis: Understanding cellular equilibrium.
- Innate Immunity: Investigating the body's first line of defense.
- Post-Translational Modifications: Decoding protein functionality.
- Pathogen-Host Interactions: Illuminating the battle between microbes and hosts.
- Vesicle Trafficking & Immune Evasion Mechanisms: Uncovering cellular transport and immune strategies.
Her team employs cutting-edge methods such as automated high-content microscopy, genetics, proteomics, molecular biology, and biochemical assays.
🌍 IMPACT AND INFLUENCE
Dr. Herhaus’s groundbreaking research has been pivotal in understanding cellular signaling pathways and immune responses, with implications in quality control, cancer biology, and host-pathogen dynamics. Her recognition extends to multiple honors, including the Tim Hunt Prize and the Signal Transduction Society Science Award.
📊 ACADEMIC CITATIONS
- Total Citations: 2,070
- H-Index: 18
- i10-Index: 20
Her scholarly output highlights her influence, with contributions featured in esteemed publications and a forthcoming book chapter titled Targeting Autophagy as an Immunotherapy Strategy.
🌟 LEGACY AND FUTURE CONTRIBUTIONS
Dr. Herhaus is a rising star in molecular biology and immune research, with a vision to uncover new therapeutic avenues in cancer, immunity, and infection. Her leadership at HZI and Hannover Medical School ensures a continued impact, inspiring the next generation of scientists while advancing fundamental and translational science.
🔗 PROFESSIONAL AFFILIATIONS
- Member of STS (Signal Transduction Society)
- Member of GMB (Gesellschaft für Biochemie und Molekularbiologie) e.V.
- Member of DHV (Deutscher Hochschulverband)
📑NOTABLE PUBLICATIONS
"TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease"
- Authors: Herhaus, L. , Bhaskara, R.M. , Lystad, A.H. , Hummer, G. , Dikic, I.
- Journal: EMBO Reports
- Year: 2020
"SIK2 orchestrates actin-dependent host response upon Salmonella infection"
- Authors: Hahn, M. , Covarrubias-Pinto, A. , Herhaus, L. , Choudhary, C. , Dikic, I.
- Journal: Proceedings of the National Academy of Sciences of the United States of America
- Year: 2021
"TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease"
- Authors: Herhaus, L.
- Journal: Matrix Biology
- Year: 2021
"Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses"
- Authors: Krämer, N. , Schütz, M. , Mato, U.G. , Marschall, M. , Zimmermann, C.
- Journal: Viruses
- Year: 2022
"The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection"
- Authors: Krämer, N. , Mato, U.G. , Krauter, S. , Plachter, B. , Zimmermann, C.
- Journal: Viruses
- Year: 2024