He Chunyan | Molecular Breeding | Genetics Research Excellence Award

Dr. He Chunyan | Molecular Breeding | Genetics Research Excellence Award

Beijing Forestry University | China

Author Profile

Scopus

🌿 HE CHUNYAN: A DEDICATED RESEARCHER IN LANDSCAPE PLANTS AND MOLECULAR BREEDING

EARLY ACADEMIC PURSUITS 🎓

He Chunyan, born in August 1990 in Anyue, Sichuan, pursued her early academic training in Grassland Science at Anhui Agricultural University, earning her undergraduate degree between 2011 and 2015. Her education continued at Beijing Forestry University, where she earned both her Master's and PhD degrees, with a specialization in Landscape Plants and Ornamental Horticulture. Her early undergraduate years were marked by academic rigor, with courses in Turf Science, Weed Science, Genetics, and Plant Physiology, equipping her with a robust foundation in plant biology and agronomy. She also engaged in innovative research projects, including post-disaster fresh corn variety screening and the organic planting model of Amaranthus.

PROFESSIONAL ENDEAVORS 🚀

Throughout her academic career, Chunyan has demonstrated a strong commitment to scientific research. During her Master's and PhD at Beijing Forestry University, she contributed to various National Natural Science Foundation projects. Her primary focus included the molecular breeding of turfgrasses and the dwarfing mechanism of Kentucky bluegrass, contributing to the development of space-induced dwarf mutants. Her PhD research revolved around peony genetics, particularly in the study of candidate genes that regulate peony seed yield, a project sponsored by the National Natural Science Foundation. Chunyan's expertise spans advanced molecular biology techniques such as gene cloning, yeast two-hybrid, and Arabidopsis transgenic experiments, and she also undertook gene gun transgenic research for Kentucky bluegrass.

CONTRIBUTIONS AND RESEARCH FOCUS ON MOLECULAR BREEDING🔬

He Chunyan’s research focuses on molecular breeding, particularly in turf grasses and ornamental horticulture. She has contributed to multiple scholarly journals with notable papers on the genetics of Kentucky bluegrass and peony. Some of her significant publications include:

  • PrDA1-1 and its interacting protein PrTCP1/PrTCP9 in flare tree peony affect yield by regulating seed weight and number” in the Journal of Integrative Agriculture.
  • Dissection of allelic variation underlying floral and fruit traits in flare tree peony” submitted to Frontiers in Genetics.

In addition, her work on flavonoids and gene expression in Kentucky bluegrass has been featured in prestigious journals such as Chinese Journal of Grassland and Molecular Plant Breeding.

IMPACT AND INFLUENCE 🌱

He Chunyan has had a substantial impact on both academic and practical applications of horticultural science. Her work in molecular breeding and genetic analysis has influenced the development of plants with desired traits, such as improved seed yield and stress resistance. Her collaborations in national research projects have further contributed to advancements in plant biotechnology. Chunyan's role as an educator extends beyond the lab, where she has taught courses in Flower Genetics, Molecular Biology, and Turfgrass Science at Beijing Forestry University. Her contributions also include teaching high school students molecular experimentation, enriching young minds with hands-on scientific training.

ACADEMIC CITATIONS 📚

Her research has been widely cited in the field of plant molecular biology. Her work on Kentucky bluegrass and peony genetics has attracted attention in the fields of horticulture and genetic engineering. Her publications contribute to growing bodies of knowledge on seed yield regulation and stress response in turfgrasses, with ongoing submissions to renowned journals like Journal of Grassland Science and Journal of Genetics.

LEGACY AND FUTURE CONTRIBUTIONS 🌍

He Chunyan's career is a testament to her dedication to advancing plant molecular biology and landscape horticulture. Her contributions to the study of turfgrass and ornamental plants have significant implications for agricultural sustainability, urban greening, and environmental conservation. In the future, she is poised to make further strides in genetic engineering and molecular breeding, potentially leading breakthroughs in developing resilient and high-yielding plant varieties. Her legacy will be marked by her scientific achievements, commitment to education, and her influential role in shaping the future of plant breeding and horticultural science.

NOTABLE PUBLICATIONS 📑

"Heterologous expression of zjomt from zoysia japonica in Escherichia coli confers aluminum resistance through melatonin production" 

  • Authors: Luo, H. , He, C. , Han, L
  • Journal: PLoS ONE
  • Year: 2018

"Genome-wide analysis reveals four key transcription factors associated with cadmium stress in creeping bentgrass (Agrostis stolonifera L.)" 

  • Authors: Yuan, J. , Bai, Y. , Chao, Y. , Xie, L. , Han, L.
  • Journal: PeerJ
  • Year: 2018

"Screening of reference genes for real-time fluorescence quantitative PCR in Kentucky bluegrass" 

  • Authors: Zhang, L. , Tan, P.-H. , Teng, K. , Gan, L. , Yin, S.-X.
  • Journal: Acta Prataculturae Sinica
  • Year: 2017

Havva Ortabozkoyun | Gene Regulation | Best Researcher Award

Dr. Havva Ortabozkoyun | Gene Regulation | Best Researcher Award

University of Miami Miller School of Medical / Sylvester Cancer Center | United States

Author Profile

Orcid ID

Google Scholar

🧬 Havva Ortabozkoyun-Kara, PhD: Pioneering Epigenetics and Cancer Biology Researcher

🧑‍🎓 EARLY ACADEMIC PURSUITS

Havva Ortabozkoyun-Kara, PhD, embarked on her academic journey with a Bachelor of Science in Molecular Biology and Genetics from Middle East Technical University (METU) in Ankara, Turkey. Graduating with a stellar GPA of 3.80/4.00 in 2010, she demonstrated early on her dedication to understanding complex biological systems. Her education continued at Utrecht University in the Netherlands, where she pursued a Master of Science in Cancer Genomics and Developmental Biology. With a perfect GPA of 4.00/4.00, she excelled in this program, setting a strong foundation for her future research in cancer biology. Dr. Ortabozkoyun-Kara then achieved her PhD in Stem Cell Biology from New York University (NYU), where she graduated with a GPA of 3.89/4.00. During her doctoral studies, she delved into stem cell and developmental biology, further refining her focus on the mechanisms that drive cellular diversity and disease processes.

🧑‍🔬 PROFESSIONAL ENDEAVORS

Dr. Ortabozkoyun-Kara’s professional journey is marked by her extensive research experience in some of the most prestigious laboratories in the world. She began as a rotation student in the lab of Iannis Aifantis at NYU, where she explored the role of the ubiquitin system in cancer and stem cell function. Her doctoral research, conducted in the lab of Danny Reinberg at NYU School of Medicine, involved pioneering work on the insulation function of CTCF and the characterization of Polycomb Repressive Complex (PRC1) during differentiation. After completing her PhD, she continued her research as a Postdoctoral Fellow in the Reinberg Lab, focusing on gene regulation and the role of MAZ, CTCF, and other factors in disease processes. Currently, she holds a postdoctoral fellowship at the University of Miami Miller School of Medicine, where she is studying novel insulation factors on gene regulation during developmental and disease processes.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS ON GENE REGULATION

Dr. Ortabozkoyun-Kara’s research has significantly advanced our understanding of epigenetics, stem cell biology, and cancer biology. Her work has centered on the intricate mechanisms of gene regulation, particularly the insulation functions that control the expression of Hox genes during development and in disease states. Through innovative CRISPR genetic screens and biochemical assays, she has identified key factors that cooperate with CTCF in these processes. Her research on the differences in Polycomb Repressive Complex composition during cellular differentiation has provided new insights into how these complexes contribute to the regulation of gene expression.

🌍 IMPACT AND INFLUENCE

Dr. Ortabozkoyun-Kara’s contributions to the fields of epigenetics and stem cell biology have had a profound impact on our understanding of how genetic and biochemical mechanisms lead to cellular diversity and disease. Her findings on the role of insulation factors in gene regulation have opened new avenues for research in developmental biology and cancer, influencing the direction of studies in these fields. Her expertise is recognized internationally, and she continues to collaborate with leading scientists to push the boundaries of what we know about gene regulation and its implications for human health.

📚 ACADEMIC CITATIONS

Dr. Ortabozkoyun-Kara’s work has been widely cited in the academic community, reflecting the importance of her contributions to the scientific understanding of gene regulation. Her publications in high-impact journals are frequently referenced by other researchers in the fields of molecular biology, genetics, and biochemistry. These citations underscore the relevance of her work to ongoing research and its potential to inform new therapeutic approaches for diseases linked to epigenetic regulation.

🏆 LEGACY AND FUTURE CONTRIBUTIONS

As Dr. Ortabozkoyun-Kara continues her research at the University of Miami, her legacy is one of innovation and discovery. Her future contributions are expected to further illuminate the complex mechanisms of gene regulation and their role in development and disease. With her deep expertise in epigenetics and stem cell biology, she is poised to make significant advances in the understanding and treatment of diseases driven by genetic and epigenetic alterations. Her work will undoubtedly continue to influence the fields of molecular biology and genetics for years to come, inspiring future generations of scientists.

💡 INNOVATIVE APPROACHES

Dr. Ortabozkoyun-Kara is known for her creative and methodical approaches to scientific research. She has developed novel genetic and biochemical methods that have expanded the toolkit available to researchers studying epigenetic mechanisms. Her work not only provides critical insights but also equips the scientific community with new strategies for investigating and manipulating gene expression in various biological contexts.

📑 NOTABLE PUBLICATIONS

"CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters" 

  • Authors: Havva Ortabozkoyun, Pin-Yao Huang, Hyunwoo Cho, Varun Narendra, Gary LeRoy, Edgar Gonzalez-Buendia, Jane A Skok, Aristotelis Tsirigos, Esteban O Mazzoni, Danny Reinberg
  • Journal: Nature Genetics
  • Year: 2022

"A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters" 

  • Authors: Havva Ortabozkoyun-Kara, Pin-Yao Huang, Hyunwoo Cho, Varun Narendra, Gary Leroy, Jane A. Skok, Aristotelis Tsirigos, Esteban O. Mazzoni, Danny Reinberg
  • Journal: BioRxiv
  • Year: 2020

"Members of an array of zinc finger proteins specify distinct Hox chromatin boundaries"

  • Authors: Havva Ortabozkoyun, Pin-Yao Huang, Edgar Gonzalez-Buendia, Hyein Cho, Sang Kim, Aristotelis Tsirigos, Esteban Mazzoni, Danny Reinberg
  • Journal: bioRxiv
  • Year: 2023

"Members of a Family of Zinc Finger Proteins Demarcate Chromatin Boundaries at Hox Clusters during Development, Ortabozkoyun et. al"

  • Authors: Havva Ortabozkoyun, Pin-Yao Huang, Edgar Gonzalez-Buendia, Hyunwoo Cho, Sang Y Kim, Aristotelis Tsirigos, Esteban O Mazzoni, Danny Reinberg
  • Journal: Mendeley Data
  • Year: 2024

"Novel chromatin insulating activities uncovered upon eliminating known insulators in vivo"

  • Authors: Havva Ortabozkoyun, P. Huang, H. Cho, E. Mazzoni, A. Tsirigos, D. Reinberg
  • Year: 2023