The First Affiliated hospital of Chengdu Medical College | China
AUTHOR PROFILE
Scopus
EARLY ACADEMIC PURSUITS
Yang Xianggui embarked on his academic journey at Harbin Medical University, where he earned a Bachelor's degree in Medical Laboratory Science. He further advanced his education at Chongqing Medical University, obtaining a Master's degree in Clinical Laboratory Diagnostics from the School of Laboratory Medicine.
PROFESSIONAL ENDEAVORS
Since July 2015, Yang Xianggui has been serving as the Deputy Chief Laboratory Physician at the First Affiliated Hospital of Chengdu Medical College. His primary focus is on research into bacterial resistance mechanisms and virulence, positioning him as a significant contributor to this critical field of medical research.
Dr. Yang's research endeavors have been substantial and varied, including:
- CRISPR/Cas9 Technology: Utilizing CRISPR/Cas9 to knock out the ftsZ gene in bacteria to study the molecular regulatory mechanism of the key enzyme MpI in the peptidoglycan cycle.
- Gene Knockout Studies: Investigating the regulatory mechanism of acute-chronic infection transformation based on the nagZ gene knockout in Enterobacter cloacae.
- MicroRNA Research: Exploring the application of miR-135 in detecting early-onset chronic kidney disease.
- Enzyme and Protein Studies: Examining the correlation between Klebsiella pneumoniae KPC-2 enzyme and OmpK36, and studying the molecular regulatory mechanism of AmpC beta-lactamase, a key enzyme in the peptidoglycan cycle.
IMPACT AND INFLUENCE
Dr. Yang has been the principal investigator on several high-impact research projects funded by notable organizations:
- National Natural Science Youth Foundation Project: CRISPR/Cas9 technology study on ftsZ gene knockout.
- Sichuan Provincial Natural Science Foundation General Project: Regulatory mechanism study on acute-chronic infection transformation.
- Sichuan Provincial Department of Education Fund: Research on miR-135's application in early-onset chronic kidney disease detection.
- Chengdu Medical University Fund: Correlation study between Klebsiella pneumoniae KPC-2 enzyme and OmpK36.
- Special Fund of the First Affiliated Hospital of Chengdu Medical College: Study on the molecular regulatory mechanism of AmpC beta-lactamase.
ACADEMIC CITES
Dr. Yang has published nine SCI papers as the first author or corresponding author, showcasing his contributions to the scientific community. His work is recognized and cited by peers, reflecting his influence and expertise in bacterial resistance mechanisms and clinical laboratory diagnostics.
LEGACY AND FUTURE CONTRIBUTIONS
Dr. Yang's ongoing research projects and completed studies contribute significantly to the understanding of bacterial resistance and virulence. His legacy is built on his dedication to advancing laboratory medicine through innovative research and collaborative efforts. Future contributions are anticipated in the areas of infection control, molecular diagnostics, and bacterial resistance management, further enhancing his impact on medical science and patient care.
IMPORTANT TOPICS
- BACTERIAL RESISTANCE MECHANISMS: Exploring how bacteria develop resistance to antibiotics and identifying potential targets for new treatments.
- VIRULENCE FACTORS: Investigating the components that make bacteria pathogenic and how they can be neutralized.
- MOLECULAR REGULATORY MECHANISMS: Understanding the intricate molecular pathways that govern bacterial behavior and resistance.
- GENE KNOCKOUT TECHNOLOGIES: Utilizing advanced gene-editing tools like CRISPR/Cas9 to study bacterial genetics and physiology.
- CLINICAL APPLICATIONS: Translating research findings into practical applications in clinical diagnostics and treatment strategies.
NOTABLE PUBLICATIONS