Xiang Gui Yang | Clinical Microbiology | Best Researcher Award

Xiang Gui Yang | Clinical Microbiology | Best Researcher Award

The First Affiliated hospital of Chengdu Medical College | China

AUTHOR PROFILE

Scopus

EARLY ACADEMIC PURSUITS

Yang Xianggui embarked on his academic journey at Harbin Medical University, where he earned a Bachelor's degree in Medical Laboratory Science. He further advanced his education at Chongqing Medical University, obtaining a Master's degree in Clinical Laboratory Diagnostics from the School of Laboratory Medicine.

PROFESSIONAL ENDEAVORS

Since July 2015, Yang Xianggui has been serving as the Deputy Chief Laboratory Physician at the First Affiliated Hospital of Chengdu Medical College. His primary focus is on research into bacterial resistance mechanisms and virulence, positioning him as a significant contributor to this critical field of medical research.

CONTRIBUTIONS AND RESEARCH FOCUS ON CLINICAL MICROBIOLOGY

Dr. Yang's research endeavors have been substantial and varied, including:

  • CRISPR/Cas9 Technology: Utilizing CRISPR/Cas9 to knock out the ftsZ gene in bacteria to study the molecular regulatory mechanism of the key enzyme MpI in the peptidoglycan cycle.
  • Gene Knockout Studies: Investigating the regulatory mechanism of acute-chronic infection transformation based on the nagZ gene knockout in Enterobacter cloacae.
  • MicroRNA Research: Exploring the application of miR-135 in detecting early-onset chronic kidney disease.
  • Enzyme and Protein Studies: Examining the correlation between Klebsiella pneumoniae KPC-2 enzyme and OmpK36, and studying the molecular regulatory mechanism of AmpC beta-lactamase, a key enzyme in the peptidoglycan cycle.

IMPACT AND INFLUENCE

Dr. Yang has been the principal investigator on several high-impact research projects funded by notable organizations:

  1. National Natural Science Youth Foundation Project: CRISPR/Cas9 technology study on ftsZ gene knockout.
  2. Sichuan Provincial Natural Science Foundation General Project: Regulatory mechanism study on acute-chronic infection transformation.
  3. Sichuan Provincial Department of Education Fund: Research on miR-135's application in early-onset chronic kidney disease detection.
  4. Chengdu Medical University Fund: Correlation study between Klebsiella pneumoniae KPC-2 enzyme and OmpK36.
  5. Special Fund of the First Affiliated Hospital of Chengdu Medical College: Study on the molecular regulatory mechanism of AmpC beta-lactamase.

ACADEMIC CITES

Dr. Yang has published nine SCI papers as the first author or corresponding author, showcasing his contributions to the scientific community. His work is recognized and cited by peers, reflecting his influence and expertise in bacterial resistance mechanisms and clinical laboratory diagnostics.

LEGACY AND FUTURE CONTRIBUTIONS

Dr. Yang's ongoing research projects and completed studies contribute significantly to the understanding of bacterial resistance and virulence. His legacy is built on his dedication to advancing laboratory medicine through innovative research and collaborative efforts. Future contributions are anticipated in the areas of infection control, molecular diagnostics, and bacterial resistance management, further enhancing his impact on medical science and patient care.

IMPORTANT TOPICS

  1. BACTERIAL RESISTANCE MECHANISMS: Exploring how bacteria develop resistance to antibiotics and identifying potential targets for new treatments.
  2. VIRULENCE FACTORS: Investigating the components that make bacteria pathogenic and how they can be neutralized.
  3. MOLECULAR REGULATORY MECHANISMS: Understanding the intricate molecular pathways that govern bacterial behavior and resistance.
  4. GENE KNOCKOUT TECHNOLOGIES: Utilizing advanced gene-editing tools like CRISPR/Cas9 to study bacterial genetics and physiology.
  5. CLINICAL APPLICATIONS: Translating research findings into practical applications in clinical diagnostics and treatment strategies.

NOTABLE PUBLICATIONS

PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection 2023(4)

Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure 2023(3)

Application of Single-Cell Genomics in Cardiovascular Research 2023(2)

Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex 2023(3)

Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression 2021(33)

Nimisha Sharma | Molecular Genetics and DNA Sequencing | Editorial Board Member

Dr. Nimisha Sharma | Molecular Genetics and DNA Sequencing | Editorial Board Member

Indian Agricultural Research Institute | New Delhi

Author Profile

Scopus

Orcid ID

EARLY ACADEMIC PURSUITS:

Dr. Nimisha Sharma embarked on her academic journey at SKRAU, Bikaner, achieving academic excellence from the onset. Graduating with a B.Sc. Ag. (Hons.) in 2004, she secured a remarkable CGPA of 8.18, earning the prestigious Gold Medal for her outstanding performance. This set the stage for her further educational pursuits in the field of Biotechnology.

PROFESSIONAL ENDEAVORS:

Following her academic accomplishments, Dr. Nimisha Sharma ventured into the professional realm as a Senior Scientist in Plant Biotechnology. She is currently affiliated with the Division of Fruits and Horticultural Technology at ICAR-Indian Agricultural Research Institute in New Delhi.

CONTRIBUTIONS AND RESEARCH FOCUS ON MOLECULAR GENETICS AND DNA SEQUENCING:

Dr. Sharma's Ph.D. thesis, titled "Assessment of microbial diversity in western Rajasthan under Thar desert," reflects her commitment to understanding and contributing to the agricultural ecosystem, particularly in arid regions. Under the guidance of Dr. Govind Singh at SKRAU, Bikaner, she successfully defended her thesis in 2012.

IMPACT AND INFLUENCE:

Dr. Nimisha Sharma's work has had a notable impact, particularly in the assessment of microbial diversity in challenging environments. Her research contributes to the broader understanding of sustainable agricultural practices, especially in arid regions like western Rajasthan.

ACADEMIC CITATIONS:

Dr. Sharma's contributions have likely been recognized in academic circles, with her work potentially garnering citations and references in the field of agricultural biotechnology and microbial diversity research.

LEGACY AND FUTURE CONTRIBUTIONS:

With a solid foundation in academic achievements, professional experience, and impactful research, Dr. Nimisha Sharma is poised to leave a lasting legacy in the field of Plant Biotechnology. Her focus on addressing agricultural challenges in arid regions sets the stage for future contributions, indicating a trajectory of sustained impact on agricultural practices and research methodologies.

Notable Publications:

Rootstock-mediated carbohydrate metabolism, nutrient contents, and physiological modifications in regular and
alternate mango (Mangifera indica L.) scion varieties 2023(2)

Elucidation of Physio-Biochemical Changes in Citrus spp. Incited by Xanthomonas citri pv. citri 2023(3)

Scion/Rootstock Interaction Studies for Quality Traits in Mango (Mangifera indica L.) Varieties 2023(2)