Xiamen University | China
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🌟 Biography of Dr. Liang Liu 🌟
🎓 EARLY ACADEMIC PURSUITS
Dr. Liang Liu began his journey in the field of life sciences with a Bachelor of Science degree from the School of Life Sciences, South-Central University for Nationalities (2006–2010). His academic curiosity led him to pursue a Ph.D. at the School of Biology and Biological Engineering, South China University of Technology, where he delved into the intricate world of molecular biology (2010–2015).
🏛️ PROFESSIONAL ENDEAVORS
After earning his Ph.D., Dr. Liu undertook postdoctoral research at the prestigious Institute of Biophysics, Chinese Academy of Sciences (2015–2019). Since 2019, he has been a professor at the School of Life Sciences, Xiamen University. He also holds roles as a professor at the State Key Laboratory of Cell Stress Biology and Xiang’an Hospital Affiliated to Xiamen University.
Dr. Liu's leadership and expertise are further amplified through his contributions as a doctoral supervisor, shaping the next generation of researchers in molecular biology and gene editing.
Dr. Liang Liu’s research portfolio spans cutting-edge domains:
- Gene Editing and Diagnostic Tools: Developing and applying innovative tools for gene editing and molecular diagnostics.
- Prokaryotic Defense and Viral Antagonism: Exploring molecular mechanisms of prokaryotic defense systems, including CRISPR-Cas systems, and viral strategies for evading host immunity.
- Nucleic Acid Processing: Investigating RNA processing, regulation, and nucleic acid methylation modifications.
- Structural Biology of RNA: Elucidating RNA-mediated gene expression and regulation through advanced structural biology techniques.
His groundbreaking research has unveiled mechanisms underlying prokaryotic resistance to viruses and contributed to the development of novel gene-editing tools and efficient molecular diagnostic systems.
🏆 HONORS AND AWARDS
Dr. Liu’s exemplary contributions have earned him multiple prestigious honors, including:
- Outstanding Youth Science Foundation Award (2020).
- Young Top Talents Program, Xiamen University (2019).
- Young Talents Support Project, China Association for Science and Technology (2018).
- Second Prize, Beijing Science and Technology Award (2018).
🌍 IMPACT AND INFLUENCE
Dr. Liu has significantly advanced the understanding of prokaryotic defense systems, especially the CRISPR-Cas system. His insights into Cas nuclease mechanisms have laid the foundation for transformative molecular diagnostic tools. He has also pioneered innovative gene-editing tools, expanding the potential for therapeutic applications.
Through his role as a researcher and educator, he has mentored numerous students, fostering talent in molecular biology and structural biology.
📚 ACADEMIC CITATIONS
Dr. Liu’s research is widely recognized in the scientific community. He has published extensively as a corresponding, co-corresponding, or first author in leading journals such as:
- Cell
- Nature Biotechnology
- Molecular Cell
- Nature Communications
- eLife
- Structure
His contributions have attracted numerous citations, reflecting his research's profound influence and relevance.
🌟 LEGACY AND FUTURE CONTRIBUTIONS
Dr. Liu’s legacy in molecular biology lies in his impactful work on the mechanisms of prokaryotic defense, innovative diagnostic tools, and advancements in RNA-based research. Moving forward, he is poised to drive significant breakthroughs in epigenetic inheritance, nucleic acid manipulation, and biomedical applications of gene-editing technologies. His continued efforts will undoubtedly contribute to shaping the future of molecular diagnostics and therapeutics.
📑 NOTABLE PUBLICATIONS
"Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States"
- Authors: Sun, W. , Yang, J. , Cheng, Z. , Sontheimer, E.J. , Wang, Y.
- Journal: Molecular Cell
- Year: 2019
"Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race"
- Authors: Liu, L. , Yin, M. , Wang, M. , Wang, Y.
- Journal: Molecular Cell
- Year: 2019
"Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference"
- Authors: You, L. , Ma, J. , Wang, J. , Zhang, X. , Wang, Y.
- Journal: Cell
- Year: 2019
"A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment"
- Authors: Zhao, X. , Liu, L. , Lang, J. , Wang, Y. , Nie, G.
- Journal: Cancer Letters
- Year: 2018
"The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a"
- Authors: Liu, L. , Li, X. , Ma, J. , Zhang, X. , Wang, Y.
- Journal: Cell
- Year: 2017