Liang Liu | Molecular Neuroscience | Best Researcher Award

Prof. Dr. Liang Liu | Molecular Neuroscience | Best Researcher Award

Xiamen University | China

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🌟 Biography of Dr. Liang Liu 🌟

🎓 EARLY ACADEMIC PURSUITS

Dr. Liang Liu began his journey in the field of life sciences with a Bachelor of Science degree from the School of Life Sciences, South-Central University for Nationalities (2006–2010). His academic curiosity led him to pursue a Ph.D. at the School of Biology and Biological Engineering, South China University of Technology, where he delved into the intricate world of molecular biology (2010–2015).

🏛️ PROFESSIONAL ENDEAVORS

After earning his Ph.D., Dr. Liu undertook postdoctoral research at the prestigious Institute of Biophysics, Chinese Academy of Sciences (2015–2019). Since 2019, he has been a professor at the School of Life Sciences, Xiamen University. He also holds roles as a professor at the State Key Laboratory of Cell Stress Biology and Xiang’an Hospital Affiliated to Xiamen University.

Dr. Liu's leadership and expertise are further amplified through his contributions as a doctoral supervisor, shaping the next generation of researchers in molecular biology and gene editing.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS ON MOLECULAR NEUROSCIENCE

Dr. Liang Liu’s research portfolio spans cutting-edge domains:

  1. Gene Editing and Diagnostic Tools: Developing and applying innovative tools for gene editing and molecular diagnostics.
  2. Prokaryotic Defense and Viral Antagonism: Exploring molecular mechanisms of prokaryotic defense systems, including CRISPR-Cas systems, and viral strategies for evading host immunity.
  3. Nucleic Acid Processing: Investigating RNA processing, regulation, and nucleic acid methylation modifications.
  4. Structural Biology of RNA: Elucidating RNA-mediated gene expression and regulation through advanced structural biology techniques.

His groundbreaking research has unveiled mechanisms underlying prokaryotic resistance to viruses and contributed to the development of novel gene-editing tools and efficient molecular diagnostic systems.

🏆 HONORS AND AWARDS

Dr. Liu’s exemplary contributions have earned him multiple prestigious honors, including:

  • Outstanding Youth Science Foundation Award (2020).
  • Young Top Talents Program, Xiamen University (2019).
  • Young Talents Support Project, China Association for Science and Technology (2018).
  • Second Prize, Beijing Science and Technology Award (2018).

🌍 IMPACT AND INFLUENCE

Dr. Liu has significantly advanced the understanding of prokaryotic defense systems, especially the CRISPR-Cas system. His insights into Cas nuclease mechanisms have laid the foundation for transformative molecular diagnostic tools. He has also pioneered innovative gene-editing tools, expanding the potential for therapeutic applications.

Through his role as a researcher and educator, he has mentored numerous students, fostering talent in molecular biology and structural biology.

📚 ACADEMIC CITATIONS

Dr. Liu’s research is widely recognized in the scientific community. He has published extensively as a corresponding, co-corresponding, or first author in leading journals such as:

  • Cell
  • Nature Biotechnology
  • Molecular Cell
  • Nature Communications
  • eLife
  • Structure

His contributions have attracted numerous citations, reflecting his research's profound influence and relevance.

🌟 LEGACY AND FUTURE CONTRIBUTIONS

Dr. Liu’s legacy in molecular biology lies in his impactful work on the mechanisms of prokaryotic defense, innovative diagnostic tools, and advancements in RNA-based research. Moving forward, he is poised to drive significant breakthroughs in epigenetic inheritance, nucleic acid manipulation, and biomedical applications of gene-editing technologies. His continued efforts will undoubtedly contribute to shaping the future of molecular diagnostics and therapeutics.

📑 NOTABLE PUBLICATIONS 

"Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States

  • Authors: Sun, W. , Yang, J. , Cheng, Z. , Sontheimer, E.J. , Wang, Y.
  • Journal: Molecular Cell
  • Year: 2019

"Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race

  • Authors: Liu, L. , Yin, M. , Wang, M. , Wang, Y.
  • Journal: Molecular Cell
  • Year: 2019

"Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

  • Authors: You, L. , Ma, J. , Wang, J. , Zhang, X. , Wang, Y.
  • Journal: Cell
  • Year: 2019

"A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment

  • Authors: Zhao, X. , Liu, L. , Lang, J. , Wang, Y. , Nie, G.
  • Journal: Cancer Letters
  • Year: 2018

"The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a

  • Authors: Liu, L. , Li, X. , Ma, J. , Zhang, X. , Wang, Y.
  • Journal: Cell
  • Year: 2017

Yulian Ding | Molecular Basis of Genetic Disease | Best Researcher Award

Dr. Yulian Ding | Molecular Basis of Genetic Disease | Best Researcher Award

Shenzhen Institute of Advanced Technology | China

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🧬 YULIAN DING, PH.D. – PIONEER IN BIOMEDICAL ENGINEERING AND MACHINE LEARNING

EARLY ACADEMIC PURSUITS🎓

Yulian Ding embarked on her academic journey with a Bachelor of Science in Computer Science from Luoyang Normal University (2010-2014). Her passion for data science and bioinformatics was further solidified during her Master's degree in Computer Science at Shaanxi Normal University (2014-2017), where she focused on dynamic protein complex identification and essential protein identification through swarm intelligence optimization. Her research, under the guidance of Dr. Xiujuan Lei, shaped her understanding of computational biology and bioinformatics. In 2018, Yulian took her academic prowess to the next level by pursuing a Ph.D. in Biomedical Engineering at the University of Saskatchewan (2018-2022). Under the supervision of Dr. Fang-Xiang Wu, she developed advanced machine learning models to predict biomolecule-disease associations, working with miRNAs, lncRNAs, and circRNA.

PROFESSIONAL ENDEAVORS🧑‍🔬

Upon completing her Ph.D., Yulian Ding transitioned into various research roles that leveraged her expertise in both machine learning and biomedical engineering. From March 2022 to February 2023, she served as an Assistant Researcher at the Center for High Performance Computing, Shenzhen Institute of Advanced Technology, under the prestigious Chinese Academy of Sciences. Her work there focused on drug design and disease biomarker identification using machine learning techniques, contributing to major advancements in protein-ligand interaction prediction. Concurrently, Yulian completed a Postdoctoral Fellowship at the University of Saskatchewan’s College of Medicine and Division of Biomedical Engineering. She specialized in bio-data analytics, working on clinical data, particularly in identifying cirRNA biomarkers for cancer.

CONTRIBUTIONS AND RESEARCH FOCUS ON MOLECULAR BASIS OF GENETIC DISEASE🔬

Yulian Ding’s research focuses on biomedical informatics, particularly at the intersection of machine learning and biomolecular interaction. Her key contributions lie in:

  • Developing novel machine learning models for predicting disease-associated biomolecules, including miRNAs, lncRNAs, and circRNA.
  • Drug design and disease biomarker discovery, particularly through the integration of machine learning in protein-ligand interactions.
  • Enhancing the understanding of bio-data analytics in oncology, utilizing vast datasets to identify crucial molecular targets for treatment.

IMPACT AND INFLUENCE🌍

Ding's work has had significant implications in precision medicine, especially in the early detection of diseases through biomarker identification. Her research on biomolecule-disease associations and the use of machine learning for drug discovery has positioned her as a rising leader in the biomedical engineering field. Her collaboration with leading scientists and institutions, including her postdoctoral work, has influenced both academic research and practical applications in biotechnology.

ACADEMIC CITES📚

Yulian Ding has been recognized for her academic excellence through numerous prestigious awards:

  • Dr. Victor A. Pollak and Mirka B. Pollak Scholarship (2021, University of Saskatchewan)
  • Russell (Russ) William Haid Memorial Award (2020, University of Saskatchewan)
  • China’s National Scholarship for Graduate Students (2017)
  • China’s National Second Prize of Lanqiao Cup Software Design Competition (2014)
  • ACM Programming Competition Silver Medal (2014)

Her work has been published in leading academic journals and recognized by international peers in the fields of bioinformatics and computational biology. As a journal reviewer for notable journals like Neurocomputing, Knowledge-Based Systems, and PLOS Computational Biology, she has contributed to shaping future research trends.

LEGACY AND FUTURE CONTRIBUTIONS🔮

Yulian Ding's legacy is deeply intertwined with her pioneering work in biomedical engineering. By harnessing the power of machine learning, she has opened new avenues for disease diagnosis and drug development. Her future endeavors are poised to push the boundaries of biomedical innovation, with a continued focus on applying computational intelligence to solve biomedical challenges. Through ongoing research and collaboration, Yulian will undoubtedly remain at the forefront of biomedical science, contributing to innovations that bridge the gap between computation and medicine.

 FINAL THOUGHTS🏅

Yulian Ding's academic journey, professional achievements, and innovative research establish her as a significant figure in biomedical engineering. Her work continues to make impactful contributions to precision medicine and biomedical informatics, shaping the future of healthcare through cutting-edge machine learning applications.

NOTABLE PUBLICATIONS📑

"MRDPDA: A multi-Laplacian regularized deepFM model for predicting piRNA-disease associations" 

  • Authors: Liu, Y. , Zhang, F. , Ding, Y. , Li, J. , Wu, F.-X.
  • Journal: Cellular and Molecular Medicine
  • Year: 2024

"P4PC: A Portal for Bioinformatics Resources of piRNAs and circRNAs" 

  • Authors: Liu, Y., Li, R., Ding, Y., Hei, X., Wu, F.-X.
  • Journal: Bioinformatics
  • Year: 2024

"Negative sample selection for miRNA-disease association prediction models" 

  • Authors: Ding, Y. , Wang, F. , Zhang, Y. , Wu, F.-X.
  • Journal: Machine Learning Methods for Multi-Omics Data Integration
  • Year: 2023

"Biomarker Identification via a Factorization Machine-Based Neural Network With Binary Pairwise Encoding" 

  • Authors: Ding, Y. , Lei, X. , Liao, B. , Wu, F.-X
  • Journal: IEEE/ACM Transactions on Computational Biology and Bioinformatics
  • Year: 2023

"MLRDFM: a multi-view Laplacian regularized DeepFM model for predicting miRNA-disease associations" 

  • Authors: Ding, Y. , Lei, X. , Liao, B. , Wu, F.-X
  • Journal: Briefings in Bioinformatics
  • Year: 2022