Haifeng Shi | Infectious Diseases | Excellence in ResearchĀ 

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Dr. Haifeng Shi | Infectious Diseases | Excellence in ResearchĀ 

Jiangsu University | China

Author Profile

Scopus

Dr. Shi Haifeng: Pioneer in Metal Toxicology and Cell Damage Detection šŸ”¬

EARLY ACADEMIC PURSUITS šŸŽ“

Dr. Shi Haifeng's academic journey began with a Bachelorā€™s degree in Biochemistry from Nanjing University in 1998. His passion for biochemistry led him to pursue a Ph.D. at the Hong Kong University of Science and Technology, where he studied under the mentorship of Professor Hong Xue, earning his doctorate in 2002. This foundation set the stage for his future groundbreaking research in the field of metal ion metabolism and toxicity.

PROFESSIONAL ENDEAVORS šŸ§‘ā€šŸ”¬

After obtaining his Ph.D., Dr. Shi continued his work at the Hong Kong University of Science and Technology as a Research Associate from 2002 to 2004, further honing his research skills. He then embarked on an international academic experience as a Visiting Scholar at the National Institutes of Health (NIH), specifically within the Liver Diseases Branch of the NIDDK, from 2004 to 2009. His time at the NIH allowed him to deepen his expertise in molecular toxicology and disease mechanisms.

CONTRIBUTIONS AND RESEARCH FOCUS ON INFECTIOUS DISEASESšŸ§Ŗ

Dr. Shiā€™s research is focused on the metabolism and biological toxicity of metal ions such as iron, copper, and cadmium. His work is crucial in understanding how these metals impact biological systems, particularly in the context of heavy metal nephropathy. Additionally, his innovative work on the use of cell-free circulating cfDNA in blood as a biomarker for tissue cell damage has broad applications in medical diagnostics and environmental toxicology.Ā His experimental models, which include yeast, silkworms, and mice, have helped to clarify the toxicological effects of metals at both molecular and systemic levels.

IMPACT AND INFLUENCE šŸŒ

Dr. Shiā€™s contributions to the scientific community are widely recognized. He has published over 70 research papers in prestigious international journals. One of his papers was recommended by Professor Alan Parrish from the University of Missouri-Columbia and listed by "Faculty Opinions" (formerly F1000Prime), a distinction reserved for papers with significant impact on their field. Another of his publications has been selected as an ESI Highly Cited Paper, placing him among the top 1% of researchers in his field.

ACADEMIC CITATIONS šŸ“š

Dr. Shiā€™s work is highly cited, and his recognition as an ESI Highly Cited Researcher underscores his influence on the global scientific community. His papers continue to guide researchers in the fields of toxicology, nephropathy, and medical diagnostics.

LEGACY AND FUTURE CONTRIBUTIONS šŸ…

Dr. Shi Haifengā€™s legacy lies in his groundbreaking work on the biological effects of heavy metals and his innovative use of cfDNA in disease detection. As a leader in his field, his future contributions are expected to expand the frontiers of biochemistry and toxicology, with significant implications for both environmental health and clinical medicine.Ā His continued dedication to both research and education ensures that he will remain an influential figure in his field for years to come.

NOTABLE PUBLICATIONS šŸ“‘

"Cadmium promoted LPS-induced inflammation through TLR4/IĪŗBĪ±/NFĪŗ-B signaling by increasing ROS-mediated incomplete autophagy"Ā 

  • Authors: Guo, C. , Ruan, J. , Li, Z. , Gu, J. , Shi, H.
  • Journal: Ecotoxicology and Environmental Safety
  • Year: 2024

"From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death"Ā 

  • Authors: Gu, J. , Guo, C. , Ruan, J. , Gong, X. , Shi, H.
  • Journal: Apoptosis
  • Year: 2024

"Stimuli-triggered multilayer films in response to temperature and ionic strength changes for controlled favipiravir drug release"Ā 

  • Authors: Xu, L. , He, L. , Li, Y. , Shi, H. , Zhu, C.
  • Journal: Biomedical Materials (Bristol)
  • Year: 2024

"Energy storage enabled by cross-linked multilayer films using block copolymer-modified nanocapsules and chitosan biopolymers"Ā 

  • Authors: Xu, L. , Li, Y. , Cai, T. , Chu, Z. , Shen, X
  • Journal: Macromolecular Research
  • Year: 2024

"Analysis of the primary factors influencing donor derived cell-free DNA testing in kidney transplantation"Ā 

  • Authors: Cao, C. , Yuan, L. , Wang, Y. , Shi, H. , Jiang, T.
  • Journal: Frontiers in Immunology
  • Year: 2024

Xiang Gui Yang | Clinical Microbiology | Best Researcher Award

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Xiang Gui Yang | Clinical Microbiology | Best Researcher Award

The First Affiliated hospital of Chengdu Medical College | China

AUTHOR PROFILE

Scopus

EARLY ACADEMIC PURSUITS

Yang Xianggui embarked on his academic journey at Harbin Medical University, where he earned a Bachelor's degree in Medical Laboratory Science. He further advanced his education at Chongqing Medical University, obtaining a Master's degree in Clinical Laboratory Diagnostics from the School of Laboratory Medicine.

PROFESSIONAL ENDEAVORS

Since July 2015, Yang Xianggui has been serving as the Deputy Chief Laboratory Physician at the First Affiliated Hospital of Chengdu Medical College. His primary focus is on research into bacterial resistance mechanisms and virulence, positioning him as a significant contributor to this critical field of medical research.

CONTRIBUTIONS AND RESEARCH FOCUS ON CLINICAL MICROBIOLOGY

Dr. Yang's research endeavors have been substantial and varied, including:

  • CRISPR/Cas9 Technology: Utilizing CRISPR/Cas9 to knock out the ftsZ gene in bacteria to study the molecular regulatory mechanism of the key enzyme MpI in the peptidoglycan cycle.
  • Gene Knockout Studies: Investigating the regulatory mechanism of acute-chronic infection transformation based on the nagZ gene knockout in Enterobacter cloacae.
  • MicroRNA Research: Exploring the application of miR-135 in detecting early-onset chronic kidney disease.
  • Enzyme and Protein Studies: Examining the correlation between Klebsiella pneumoniae KPC-2 enzyme and OmpK36, and studying the molecular regulatory mechanism of AmpC beta-lactamase, a key enzyme in the peptidoglycan cycle.

IMPACT AND INFLUENCE

Dr. Yang has been the principal investigator on several high-impact research projects funded by notable organizations:

  1. National Natural Science Youth Foundation Project: CRISPR/Cas9 technology study on ftsZ gene knockout.
  2. Sichuan Provincial Natural Science Foundation General Project: Regulatory mechanism study on acute-chronic infection transformation.
  3. Sichuan Provincial Department of Education Fund: Research on miR-135's application in early-onset chronic kidney disease detection.
  4. Chengdu Medical University Fund: Correlation study between Klebsiella pneumoniae KPC-2 enzyme and OmpK36.
  5. Special Fund of the First Affiliated Hospital of Chengdu Medical College: Study on the molecular regulatory mechanism of AmpC beta-lactamase.

ACADEMIC CITES

Dr. Yang has published nine SCI papers as the first author or corresponding author, showcasing his contributions to the scientific community. His work is recognized and cited by peers, reflecting his influence and expertise in bacterial resistance mechanisms and clinical laboratory diagnostics.

LEGACY AND FUTURE CONTRIBUTIONS

Dr. Yang's ongoing research projects and completed studies contribute significantly to the understanding of bacterial resistance and virulence. His legacy is built on his dedication to advancing laboratory medicine through innovative research and collaborative efforts. Future contributions are anticipated in the areas of infection control, molecular diagnostics, and bacterial resistance management, further enhancing his impact on medical science and patient care.

IMPORTANT TOPICS

  1. BACTERIAL RESISTANCE MECHANISMS: Exploring how bacteria develop resistance to antibiotics and identifying potential targets for new treatments.
  2. VIRULENCE FACTORS: Investigating the components that make bacteria pathogenic and how they can be neutralized.
  3. MOLECULAR REGULATORY MECHANISMS: Understanding the intricate molecular pathways that govern bacterial behavior and resistance.
  4. GENE KNOCKOUT TECHNOLOGIES: Utilizing advanced gene-editing tools like CRISPR/Cas9 to study bacterial genetics and physiology.
  5. CLINICAL APPLICATIONS: Translating research findings into practical applications in clinical diagnostics and treatment strategies.

NOTABLE PUBLICATIONS

PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection 2023(4)

Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure 2023(3)

Application of Single-Cell Genomics in Cardiovascular Research 2023(2)

Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex 2023(3)

Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression 2021(33)