William Hanna Kutteh | Chromosomal Abnormalities | Excellence in Research 

Prof Dr. William Hanna Kutteh | Chromosomal Abnormalities | Excellence in Research 

University of Tennessee HSC and Baptist Women's Hospital | Unites States

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🌟 Biography of William Hanna Kutteh, MD, PhD, HCLD, CC 🌟

William Hanna Kutteh is a distinguished physician, scientist, and educator with an exceptional career in reproductive endocrinology, obstetrics, and gynecology. His contributions span across academic research, clinical excellence, and education, solidifying his legacy as a pioneer in reproductive health.

🏛️ EARLY ACADEMIC PURSUITS

William Hanna Kutteh embarked on his academic journey at Wake Forest University, earning a Bachelor of Arts in Biology with a minor in Chemistry (1971-1975). His keen interest in immunology led him to pursue graduate studies at Duke University, where he took advanced courses in immunology under the mentorship of Dr. Jeff Dawson (1975-1978).

He furthered his research with a Ph.D. in Molecular Cell Biology and Immunology from the University of Alabama at Birmingham (1978-1981), mentored by Dr. Jiri Mestecky. Following this, he achieved his MD at the Wake Forest University School of Medicine (1981-1985).

🩺 PROFESSIONAL ENDEAVORS

Key Positions

Dr. Kutteh has held prominent positions across leading institutions:

  • Founding Partner & Director at the Fertility Associates of Memphis
  • Professor of Obstetrics and Gynecology, University of Tennessee Health Sciences Center
  • Clinical Professor, Vanderbilt University Medical Center
  • Consulting Gynecologist, St. Jude Children’s Research Hospital, where he founded the Fertility Preservation Program

Special Roles

  • Director of Reproductive Endocrinology and Infertility at Baptist Memorial Hospital
  • Director of Resident Research Program, fostering the next generation of reproductive specialists
  • Director of EMIGS Simulation Training, advancing minimally invasive gynecologic surgery training

🔬 CONTRIBUTIONS AND RESEARCH FOCUS ON CHROMOSOMAL ABNORMALITIES

Dr. Kutteh’s research encompasses:

  1. Reproductive Immunology: Exploring immunological causes of recurrent pregnancy loss.
  2. Fertility Preservation: Pioneering techniques for cancer patients.
  3. Endocrine Disorders: Advancing treatments in reproductive endocrinology and infertility.
  4. Minimally Invasive Surgery: Innovating gynecological surgical techniques.

His dedication to translational medicine bridges the gap between laboratory research and clinical application, improving patient outcomes.

🌍 IMPACT AND INFLUENCE

Dr. Kutteh has significantly impacted:

  • Patient Care: As a reproductive endocrinologist, he has transformed the lives of countless families.
  • Medical Education: Training residents and fellows in cutting-edge reproductive techniques.
  • Research: Leading groundbreaking studies funded by the NIH, such as a prestigious R01 grant from the National Institutes of Child Health and Human Development (1995-1999).

📚 ACADEMIC CITATIONS

Dr. Kutteh's scholarly contributions include:

  • Numerous peer-reviewed publications in high-impact journals.
  • Regular faculty roles at national and international conferences such as ASRM, ESHRE, and FASEB, where his expertise in early pregnancy and immunology is widely sought after.
  • Recognition by Newsweek and US News & World Report as one of the top reproductive endocrinologists in America.

🏅 HONORS AND AWARDS

Dr. Kutteh's accolades include:

  • America’s Top Doctors by Castle Connolly (1996-2022)
  • Top Reproductive Endocrinologist by US News & World Report (2012)
  • Louie C. Henry Faculty Award for excellence in clinical teaching (2024)

He has also received numerous Sigma Xi Research Awards and service awards from professional societies, such as the American Society for Reproductive Medicine (ASRM).

💡 LEGACY AND FUTURE CONTRIBUTIONS

Dr. Kutteh’s legacy is marked by his dual commitment to advancing reproductive medicine and mentoring future leaders in the field. His ongoing work in fertility preservation, reproductive immunology, and minimally invasive surgery ensures his enduring influence.

As a visionary, he continues to push the boundaries of reproductive health through research, innovation, and education, shaping a brighter future for patients and practitioners alike.

📑NOTABLE PUBLICATIONS 

"Response: Would surgical retrieval of product of conception for the purpose of genetic analysis increase the risk of intra uterine adhesions?

  • Authors: Kutteh, W.H. , Maisenbacher, M. , Dahdouh, E.M.
  • Journal: Reproductive BioMedicine Online
  • Year: 2024

"Cell-Free DNA Analysis of Fetal Aneuploidies in Early Pregnancy Loss

  • Authors: Kutteh, W.H. , Miller, C.E. , Park, J.K. , Bhatt, S. , Keefe, D.L.
  • Journal: Journal of Clinical Medicine
  • Year: 2024

"Role of genetic analysis of products of conception and PGT in managing early pregnancy loss

  • Authors: Kutteh, W.H. , Papas, R.S. , Maisenbacher, M.K. , Dahdouh, E.M.
  • Journal: Reproductive BioMedicine Online
  • Year: 2024

"Expanding the role of chromosomal microarray analysis in the evaluation of recurrent pregnancy loss

  • Authors: Eliwa, J. , Papas, R.S. , Kutteh, W.H.
  • Journal: Journal of Reproductive Immunology
  • Year: 2024

"Is it time for new guidelines for recurrent pregnancy loss integrating genetic testing of products of conception and preimplantation genetic testing?

  • Authors: Kutteh, W.H. , Papas, R.S. , Dahdouh, E.M.
  • Journal: Fertility and Sterility
  • Year: 2024

Flavio Faletra | Cardiovascular Genetics and Genomics | Best Researcher Award 

Dr. Flavio Faletra | Cardiovascular Genetics and Genomics | Best Researcher Award 

University Health Authority of Central Friuli | Italy

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Biography of Flavio Faletra: A Leader in Medical Genetics 🧬

EARLY ACADEMIC PURSUITS 🎓

Flavio Faletra began his distinguished academic journey at the University of Trieste, where he earned a Degree in Medicine and Surgery in 2005. He further specialized in Medical Genetics at the same institution, completing his specialization in 2009. Demonstrating a strong commitment to his field, Faletra pursued advanced education with a Second-level Master’s degree in Clinical Genetics from the University of Siena in 2011. His foundational academic achievements laid the groundwork for a career focused on the intersection of genetics and clinical medicine.

PROFESSIONAL ENDEAVORS 🏥

Flavio Faletra has held multiple pivotal roles in medical genetics. Since August 2023, he has been an Expert in Genetics at the Regional Health Coordination Agency (ARCS) in Friuli Venezia Giulia, Italy. Alongside his expert role, he has been a University Lecturer on contract at the University of Trieste from 2018 to 2023, contributing to the academic growth of students in the field of genetics. His professional journey includes numerous positions as a Medical Director I Level in Medical Genetics, starting with the IRCCS Burlo Garofolo (2013–2017) and progressing through roles in University Health Authority Friuli Centrale and IRCCS Burlo Garofolo until his current position, reflecting his leadership in the medical genetics field.

CONTRIBUTIONS AND RESEARCH FOCUS ON CARDIOVASCULAR GENETICS AND GENOMICS  🔬

Faletra’s research focus spans various critical areas of medical genetics, from pediatric endocrinology to rare genetic diseases. He has contributed extensively to genetic counseling and clinical genetics, with a strong emphasis on pediatric genetic disorders. His work as a Thesis Co-Surveyor and PhD Supervisor at the University of Trieste demonstrates his dedication to nurturing the next generation of geneticists. Through courses such as the Genetic Consulting in Medical Genetics Specialization School, he has shaped the landscape of medical genetics education. His involvement in pediatric endocrinology through ADE courses has brought syndromic genetic disorders to the forefront, significantly impacting the medical community’s approach to these conditions.

IMPACT AND INFLUENCE 🌍

Faletra’s influence extends beyond academia into clinical practice, where his expertise has helped shape genetic diagnostic strategies across Italy. His participation in national conferences, such as the National Congress of Human Genetics and seminars on genetic syndromes and diagnostics, marks him as a key figure in Italian medical genetics. Faletra's teaching and research efforts have particularly impacted the areas of growth retardation, fetal malformations, and syndromic genetic disorders, positioning him as a central figure in advancing genetic medicine in pediatrics.

ACADEMIC CITES 📚

Flavio Faletra's work has been cited in numerous academic publications, with topics ranging from genetic diagnostic methods to therapeutic approaches for rare genetic disorders. His research in exome sequencing and next-generation sequencing techniques has had a broad impact, being referenced widely in the fields of human genetics and pediatric medicine.

LEGACY AND FUTURE CONTRIBUTIONS 🏅

Faletra’s legacy lies in his dedication to medical genetics, particularly in the areas of pediatric syndromic diseases and clinical genetics. His contribution to education, research, and clinical practice has left an indelible mark on the field. Looking ahead, his ongoing role as an expert and lecturer promises continued contributions to genomic medicine and the advancement of personalized treatment for genetic disorders. Through his continuous involvement in research, teaching, and clinical practice, Faletra remains at the forefront of innovation in medical genetics, with the potential to further revolutionize the diagnosis and treatment of complex genetic diseases.

NOTABLE PUBLICATIONS 📑

"SRSF1 haploinsufficiency is responsible for a syndromic developmental disorder associated with intellectual disability" 

  • Authors: Bogaert, E., Garde, A., Gautier, T., Dermaut, B., Vitobello, A.
  • Journal: American Journal of Human Genetics
  • Year: 2023

"Haploinsufficiency as a Foreground Pathomechanism of Poirer-Bienvenu Syndrome and Novel Insights Underlying the Phenotypic Continuum of CSNK2B-Associated Disorders" 

  • Authors:Di Stazio, M., Zanus, C., Faletra, F., d’Adamo, A.P., Musante, L.
  • Journal: Genes
  • Year: 2023

"A new neurodevelopmental disorder linked to heterozygous variants in UNC79"

  • Authors: A., Liu, Z., Luo, S., Liao, W., & Ren, D.
  • Journal: Genetics in Medicine
  • Year: 2023

"The clinical impact of the first-trimester nuchal translucency between the 95th–99th percentiles"

  • Authors: Fantasia, I., Catagini, S., Zamagni, G., Feresin, A., & Stampalija, T.
  • Journal: Prenatal Diagnosis
  • Year: 2023

"A bird’s eye view on the use of whole exome sequencing in rare congenital ophthalmic diseases"

  • Authors: Zucco, J., Baldan, F., Allegri, L., Damante, G., Mio, C.
  • Journal: Journal of Human Genetics
  • Year: 2024

Erisa Mwaka | Genetics and Genomics | Best Researcher Award

Assoc Prof Dr. Erisa Mwaka | Genetics and Genomics | Best Researcher Award

Makerere University | Uganda

AUTHOR PROFILE

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EARLY ACADEMIC PURSUITS

Mwaka Erisa Sabakaki's academic journey began at Mwiri Primary School, where he earned his Primary Leaving Examination Certificate in 1986. He continued his education at Busoga College Mwiri, obtaining the Uganda Certificate of Education in 1990 and the Uganda Advanced Certificate of Education in 1992. He pursued a Bachelor of Medicine and Bachelor of Surgery at Makerere University, Kampala, from 1992 to 1997. Following this, he achieved a Master of Medicine in Orthopaedic Surgery from Makerere University between 2000 and 2003, where his thesis focused on the clinical and radiological presentation of osteonecrosis of the femoral head among sickle cell patients. He furthered his academic credentials with a Doctor of Philosophy in Medical Science from Fukui University School of Medicine in Japan, concentrating on histo-pathological and immuno-histological findings related to calcium pyrophosphate dihydrate crystal deposition in the ligamentum flavum of the cervical spine.

PROFESSIONAL ENDEAVORS

Mwaka's professional career is multifaceted, combining academic responsibilities, clinical practice, and extensive involvement in research ethics. Since December 2020, he has been an Associate Professor at Makerere University College of Health Sciences, School of Biomedical Sciences, Department of Anatomy. His clinical practice includes serving as an orthopaedic and spine surgeon at Mulago National Referral and Teaching Hospital. Additionally, he has held significant roles, such as the Chair of the Makerere University School of Biomedical Sciences Higher Degrees Research Ethics Committee (SBSHREC), where he oversees the regulation of research involving human participants and study animals.

CONTRIBUTIONS AND RESEARCH FOCUS ON GENETICS AND GENOMICS 

Mwaka's contributions to the medical field are substantial, particularly in the areas of anatomy, orthopaedics, bioethics, and health research ethics. He has a notable interest in spine conditions, occupational health, bone health in HIV, and the ethics of medical care, biobanking, and genomics. His research includes supervising graduate studies and conducting his own investigations, with a significant focus on ethical standards and the responsible conduct of research. He is a key member and co-investigator in various training programs, including the Fogarty-funded International Health Ethics Training (IHRET) master's program.

IMPACT AND INFLUENCE

Mwaka has been recognized for his significant contributions to medical education, clinical care, and research. He is a member of multiple professional organizations, including the Uganda Medical Association, Association of Surgeons of Uganda, Uganda Orthopaedic Association, and International Society of Orthopaedic Surgery and Traumatology (SICOT). His involvement in these organizations has enhanced his professional skills and fostered teamwork and communication within the medical community.

AWARDS AND HONORS

Mwaka's excellence in his field has been acknowledged through numerous awards and honors. Notably, he received the Prof. Medi Kawuma Excellence in Medical Ethics Award in 2023 from the Uganda Medical Association, recognizing his outstanding contributions to research, clinical care, and medical education. He has also been honored by the Uganda Orthopaedic Association and the South African Research Ethics Training Initiative (SARETI) for his academic and professional achievements.

ACADEMIC SITES

Mwaka has actively contributed to multiple technical advisory committees and data and safety management boards. His roles include overseeing studies on severe acute malnutrition, HIV outcomes improvement using mobile phone-based support, growth and development in stunted children, clinical trials on natural therapeutics, and respiratory interventions. His work in these areas underscores his dedication to improving health outcomes through research and ethical oversight.

LEGACY AND FUTURE CONTRIBUTIONS

Mwaka's legacy is marked by his dedication to education, clinical excellence, and ethical research practices. His contributions have significantly advanced the fields of orthopaedics, bioethics, and health research ethics. Moving forward, his continued involvement in mentoring and training future medical professionals and researchers will further solidify his impact on the medical community. His role in developing and implementing ethical guidelines for clinical research will ensure the responsible conduct of research and the protection of participants' rights and welfare.

NOTBLE PUBLICATIONS

Informed consent in cancer clinical care: Perspectives of healthcare professionals on information disclosure at a tertiary institution in Uganda 2024(1)

Evaluation of the current status of prosthetic rehabilitation services for major limb loss: a descriptive study in Ugandan Referral hospitals 2024(2)

Research Participants’ Preferences for Individual Results of Pharmacogenomics Research: A Case of a Ugandan HIV Research Institute 2023(2)

A case for routine microbial diagnostics: Results from antimicrobial susceptibility testing in post-traumatic wound infections at a Ugandan tertiary care hospital 2023(2)

Remote consent approaches for mobile phone surveys of non-communicable disease risk factors in Colombia and Uganda: A randomized study2023(1)

Paritha Arumugam | Gene Therapy | Best Researcher Award

Dr. Paritha Arumugam | Gene Therapy | Best Researcher Award

Cincinnati Children's Hospital Medical Center | United States

AUTHOR PROFILE

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EARLY ACADEMIC PURSUITS

Paritha Arumugam's academic journey began at the University of Madras, Bharathi Women's College, where she earned her B.Sc. in Biochemistry in 1991. She continued her education at the University of Madras, Guindy Campus, obtaining her M.Sc. in Biochemistry in 1993, M.Phil. in Biochemistry in 1994, and Ph.D. in Biochemistry in 1998 under the mentorship of Shyamala Devi, C.S. Her academic excellence was recognized with numerous awards, including the Gold Medal for securing the first rank in her M.Sc. program and various other prestigious prizes from the University of Madras.

PROFESSIONAL ENDEAVORS

Dr. Arumugam's professional career is marked by significant roles in both academic and research settings. She served as a Postdoctoral Research Fellow at the Children’s Hospital Los Angeles (CHLA) from 2004 to 2006, under the guidance of Dr. Punam Malik in the Division of Hematology-Oncology. She later earned an M.S. in Drug Development from the University of Cincinnati in 2011, where she was advised by Kevin L. Skare. Her academic appointments at the University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center (CCHMC) have been pivotal. She progressed from Research Instructor in Pediatrics (2015-2019) to her current position as an Assistant Professor in Pediatrics at the Translational Pulmonary Science Center, Division of Pulmonary Biology, beginning in October 2019.

CONTRIBUTIONS AND RESEARCH FOCUS ON GENE THERAPY

Dr. Arumugam's research has significantly advanced the fields of biochemistry and molecular biology, with a particular focus on translational pulmonary science. Her work on developing a novel cell transplantation therapy, specifically Pulmonary Macrophage Transplantation, earned her a plenary talk at the NHLBI Celebration of 15 Years of Basic and Translational Progenitor Cell Research in 2023. Her research has garnered numerous awards, including the Excellence in Hemoglobinopathy Research Award from the National Institutes of Health and multiple abstract and travel awards from the American Society of Hematology.

IMPACT AND INFLUENCE

Dr. Arumugam's impact extends beyond her direct research contributions. Her role in advancing clinical practices is underscored by her licensing and certification in Good Clinical Practice for clinical trials involving drugs and devices. Her expertise in conducting investigator-initiated studies according to FDA regulations and GCP has positioned her as a leader in the field, capable of managing investigational agents and overseeing the ethical conduct of clinical trials.

ACADEMIC CITES

Dr. Arumugam's academic excellence has been recognized with several citations and awards throughout her career. Notably, she has been a recipient of the Cincinnati Children’s Innovation Excellence Award in 2023 and the NHLBI Celebration of 15 Years of Basic and Translational Progenitor Cell Research Poster Award. Her scholarly contributions are also highlighted by her selection as a Translational Sickle Scholar by the National Institutes of Health.

LEGACY AND FUTURE CONTRIBUTIONS

Dr. Arumugam's legacy is defined by her dedication to advancing medical science and improving clinical practices. Her pioneering research on pulmonary macrophage transplantation and her contributions to hemoglobinopathy research underscore her commitment to translational science. Looking forward, Dr. Arumugam aims to continue her impactful research, mentor the next generation of scientists, and contribute to significant advancements in pediatric pulmonary biology and therapeutic developments.

NOTABLE PUBLICATIONS

Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia 2020(52)

FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation 2020(28)

Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment 2021(27)

Role of GM-CSF in regulating metabolism and mitochondrial functions critical to macrophage proliferation 2022(26)

A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption 2022(8)