Xinghua Pan | Next-Generation Sequencing | Research Excellence Award

Published on by Genetics and Genomics

Prof. Xinghua Pan | Next-Generation Sequencing | Research Excellence Award

Macau University of Science and Technology | China

Prof. Xinghua (Victor) Pan, PhD, MD, is a distinguished scholar in single-cell technology, genome medicine, cancer biology, regenerative medicine, and multi-omics bioinformatics, currently serving as a Professor at the Precision Regenerative Medicine Research Centre (PRMRC) in the Medical Science Division of Macau University of Science and Technology (MUST), with a secondary affiliation at the State Key Laboratory of Quality Research in Chinese Medicine. A doctoral supervisor in Biomedical Science and Pharmacy programs at MUST, Dr. Pan previously served as Chairman and Professor of Biochemistry and Molecular Biology at Southern Medical University (SMU), where he founded and led the Guangdong Provincial Key Laboratory of Single Cell Technology and Application and held multiple adjunct roles across major hospitals, universities, and national laboratories. With a career spanning Yale University—where he advanced from Associate Research Scientist to Research Scientist and PI-and leadership positions in molecular genomics companies, Dr. Pan brings decades of expertise shaped by rigorous training at Southern Medical University, Fudan University, CAMS & PUMC, and Yale University, complemented by international fellowships at Peking University, Melbourne University, the Ludwig Institute, and Cold Spring Harbor Laboratory. Renowned for pioneering single-cell sequencing innovations-including multiomics, copy-number, methylome, transcriptome, telomere, and multiplexing technologies-he has applied these breakthroughs to major biomedical challenges across cancer, stem cells, organoids, aging, infectious diseases, immunology, brain disorders, and precision medicine. Dr. Pan has authored over 160 publications in high-impact journals such as Nature, PNAS, Advanced Science, Nucleic Acids Research, and Nature Communications, accumulating more than 8,500 citations and an H-index of 40, alongside 15 issued patents in the U.S. and China. His work has been supported by national and international foundations including NSFC, NIH, NSF, MOST, and leading provincial and municipal programs. A dedicated educator who has trained over 60 researchers and taught nearly 10,000 students, he also serves as an Associate Editor of Precision Clinical Medicine and Monocytomics, reviewer for more than 30 top journals, and evaluator for major grant agencies and academic degree committees. As an organizer and keynote speaker at over 100 global conferences, including co-chairing the International Conference on Single Cell and Spatial Omics (TICSSO), Dr. Pan has also held leadership roles in multiple scientific societies and earned numerous accolades such as UICC and CSHL Scholarships, PolyGenomics Fellowship, VEBLEO Fellow, Nanjing Leading Talent, Guangzhou High-Level Talent, Ganpo Distinguished Professor, and the CastUSA Single Cell Genomics Pioneer Award, solidifying his global influence in single-cell biology and precision regenerative medicine.

Profiles: Scopus | Orcid

Featured Publications

"A medium throughput approach for single cell copy number variation sequencing towards efficient application in clinics", Guanchuan Lin; Caiming Chen; Mengchang Xu; Bin Peng; Zhanying Dong; Xuewen Zhou; Jinyu Gao; Jie Yu; Bei Jia; Chen Luo et al., 2025

"Causal effects of immune cell phenotypes on the risk of autoimmune liver diseases: a bidirectional two-sample Mendelian randomization study",Hongjie Zou; Xinghe Liang; Mengqi Luo; Xinghua Pan; De-Ke Jiang., 2025

"Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysis", Yulong Zhang; Yanfang Lu; Liyao Mai; Zebin Wen; Min Dai; Siwen Xu; Xianwei Lin; Yongjian Luo; Yinbin Qiu; Yuting Chen et al., 2025

"Transcriptomics-driven exploration of genetic variation and peptide discovery in the sea anemones Anthopleura midori and Actinia equina",Han Zhang; Xinghua Pan; Chen Weigang., 2025

Yong Xu | Cartilage Tissue | Best Researcher Award

Published on by Genetics and Genomics

Dr. Yong Xu | Cartilage Tissue | Best Researcher Award

Tongji University | China

Author Profile

Scopus

✨ XU YONG: A PIONEER IN TUMOR TREATMENT AND TISSUE REPAIR ✨

🎓 EARLY ACADEMIC PURSUITS

Xu Yong was born on May 29, 1991, in Fuzhou, Jiangxi, and pursued a career in medicine from an early age. He embarked on his academic journey at Tongji University School of Medicine, where he obtained his Bachelor of Clinical Medicine (2010-2015). With a keen interest in thoracic surgery and tissue engineering, he continued his education at Shanghai Pulmonary Hospital, earning a Master's Degree in Thoracic Surgery (2015-2018). His academic dedication led him to pursue a Ph.D. in Thoracic Surgery (2018-2021) at the same institution, where he developed expertise in tumor treatment and tissue repair.

🌟 PROFESSIONAL ENDEAVORS

Following his Ph.D., Xu Yong joined Shanghai Pulmonary Hospital as a Resident Physician (2021-2024), where he honed his clinical skills in thoracic surgery and tissue engineering. In August 2024, he transitioned to a research-focused role as a Special Associate Researcher at the Nuclear Industry 416 Hospital, Provincial Clinical Medical Research Center. His work in this position is instrumental in advancing innovative solutions for tracheal tissue engineering and regenerative medicine.

⚖️ CONTRIBUTIONS AND RESEARCH FOCUS ON CARTILAGE TISSUE

Xu Yong’s research primarily revolves around tissue engineering for cartilage regeneration, with a strong emphasis on functional tracheal reconstruction. His groundbreaking work introduced the "ring strategy", which enables the construction of bionic tracheal tissue with an alternating cartilage ring-connective tissue ring arrangement. This strategy successfully demonstrated long-term functional reconstruction of long-segment tracheal defects in rabbit models.

⚛️ MAJOR RESEARCH PROJECTS

Xu Yong has been the Principal Investigator (PI) in multiple prestigious projects, including:

  • Shanghai Science and Technology Rising Star Project (2024-2027): Focused on high-bionic tracheal tissue engineering (400,000 RMB).
  • Youth Talent Support Project (2023-2025): Dedicated to tracheal tissue engineering (300,000 RMB).
  • National Natural Science Foundation of China (2024-2026): Developing simulated tracheal tissue for large animal models (300,000 RMB).
  • Shanghai Natural Science Foundation (2022-2025): Advancing the construction of bioengineered trachea (200,000 RMB).

Additionally, he is a key participant in a major project funded by the National Natural Science Foundation of China (2,150,000 RMB), focusing on the precise matching of multiple cell types for bionic construction of long-segment trachea.

✨ IMPACT AND INFLUENCE

Xu Yong’s contributions have significantly influenced the field of tissue engineering and regenerative medicine, particularly in tracheal defect repair. His innovative biomimetic tracheal tissue construction has paved the way for improved clinical applications in treating long-segment tracheal defects. His research bridges the gap between basic science and clinical translation, offering promising therapeutic solutions for thoracic surgery.

🏆 ACADEMIC CITATIONS AND PUBLICATIONS

Xu Yong has an impressive publication record, contributing to over 30 SCI papers with a cumulative impact factor exceeding 300. His key achievements include:

  • 20 papers as first/co-first author
  • 14 papers as corresponding/co-corresponding author
  • 15 papers with an impact factor greater than 10
  • Highest single impact factor: 27.4

Notable journals where his research has been published:

  • Advanced Materials (ADV MATER)
  • Advanced Functional Materials (Adv. Funct. Mater.)
  • Advanced Science (Adv Sci.)
  • Composites Part B: Engineering (COMPOS PART B-ENG)
  • International Journal of Bioprinting (INT J BIOPRINTING)

Additionally, he holds over 10 patents related to tissue engineering and regenerative medicine.

🎬 LEGACY AND FUTURE CONTRIBUTIONS

Xu Yong’s pioneering efforts in tracheal tissue engineering and tumor treatment have established a new benchmark in the field. His ring strategy has set the foundation for future research in biomimetic tracheal reconstruction. Moving forward, he aims to:

  • Advance clinical translation of biomimetic tracheal tissue into human trials.
  • Explore novel biomaterials and tissue engineering scaffolds.
  • Collaborate on interdisciplinary projects integrating AI-driven biomaterial development.

His contributions will continue to shape the future of thoracic surgery, offering lifesaving solutions for patients with severe tracheal defects.

✨ CONCLUSION

Xu Yong is a trailblazer in regenerative medicine and thoracic surgery, whose dedication to tissue engineering and tracheal reconstruction has the potential to revolutionize the field. With a solid foundation in research, clinical expertise, and a vision for innovation, he is poised to make lasting contributions to modern medicine.

📑 NOTABLE PUBLICATIONS 

"Cartilage structure-inspired nanofiber-hydrogel composite with robust proliferation and stable chondral lineage-specific differentiation function to orchestrate cartilage regeneration for artificial tracheal construction" 

  • Authors: Y., Li, Yaqiang , X., Xun, Xiaowei , L., Duan, Liang , Y., Xu, Yong , H., Xia, Huitang
  • Journal: Bioactive Materials
  • Year: 2025

"Polydopamine-loaded microneedles for sequential tumor ablation and osteochondral regeneration" 

  • Authors: B., Lin, Bin , Y., Xu, Yong , B., Liang, Bing
  • Journal: Materials Letters
  • Year: 2025

"Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration" 

  • Authors: P., Wang, Pengli , E., Gao, Erji , T., Wang, Tao , C., Yang, Chen , L., Duan, Liang
  • Journal: Journal of Nanobiotechnology
  • Year: 2024

"3D printing of Ceffe-infused scaffolds for tailored nipple-like cartilage development" 

  • Authors: J., Ding, Jinghao , C., Wei, Chuanzhi , Y., Xu, Yong , W., Dai, Wufei , R., Chen, Ru
  • Journal: BMC Biotechnology
  • Year: 2024

"Injectable and self-healing sulfated hyaluronic acid/gelatin hydrogel as dual drug delivery system for circumferential tracheal repair" 

  • Authors: Y., Yang, Yayan , X., Zhu, Xinsheng , X., Liu, Xuezhe , N., Song, Nan , Q., Feng, Qian
  • Journal: International Journal of Biological Macromolecules
  • Year: 2024

Siyang Liu | Bioinformatics | Best Researcher Award

Published on by Genetics and Genomics

Dr. Siyang Liu | Bioinformatics | Best Researcher Award

Sun Yat-Sen University | China

Author Profile

Scopus

Orcid ID

Google Scholar

📊 Dr. Siyang Liu: A Leader in Human Statistical Genetics and Bioinformatics

EARLY ACADEMIC PURSUITS 🎓

Dr. Siyang Liu began her academic journey with a Bachelor's in Ecology from Sun Yat-sen University’s Department of Life Science (2007-2011), where she received a China National Governmental Scholarship for her academic performance. Her interest in bioinformatics led her to pursue an MSc and subsequently a Ph.D. in Bioinformatics at the Bioinformatics Center, University of Copenhagen. Supervised by esteemed Professors Anders Krogh and Anders Albrechtsen, she developed a robust foundation in bioinformatics, further supported by the Danish Government Scholarship.

PROFESSIONAL ENDEAVORS 👩‍🔬

Dr. Liu is a tenured Associate Professor at the School of Public Health (Shenzhen), Sun Yat-sen University. She also holds concurrent posts as a Professor in Genomics at BGI-Shenzhen Life-Science Institute and a Professor in Bioinformatics at the Center of Excellence for Omics Research, Beijing Tiantan Hospital. Before her current role, she was a Senior Research Scientist at BGI-Shenzhen Life-Science Institute (2018–2021).

CONTRIBUTIONS AND RESEARCH FOCUS ON BIOINFORMATICS🔬

Dr. Liu's research group primarily investigates human statistical genetics and bioinformatics. Her expertise lies in analyzing genetic, environmental, and molecular factors that contribute to human diseases and traits. She uses a combination of bioinformatics, statistical, and machine learning techniques to study the molecular and systemic etiology of complex diseases. Her goal is to develop predictive and intervention models for these diseases, benefiting individuals and populations alike.

IMPACT AND INFLUENCE 🌎

Dr. Liu’s research has contributed significantly to the understanding of complex diseases through the development of genomic and bioinformatics models. Her work is widely recognized in high-impact journals, with over 20 publications as (co-)first or (co-)corresponding author in journals such as Cell, Nature, Blood, and Nature Communications. Her findings have provided insights into both the predictive modeling of disease and the influence of various genetic and environmental factors on human health.

ACADEMIC CITES 📚

Her body of work is extensively cited in the fields of genomics, bioinformatics, and statistical genetics. This academic impact underscores the relevance and influence of her contributions to scientific knowledge, with her publications helping to advance both the understanding and practical application of complex bioinformatics models.

LEGACY AND FUTURE CONTRIBUTIONS 🌟

With her innovative research, teaching roles, and mentorship, Dr. Liu is shaping the next generation of scientists in the field of bioinformatics and public health. Her leadership in multi-omics projects, especially in the areas of cerebrovascular disease and respiratory virus research, demonstrates her commitment to advancing medical genomics and bioinformatics. Her work in population genetics and epidemiology has already made a lasting impact, and her ongoing projects promise to deepen our understanding of the genetic and environmental factors impacting public health.

KEY PROJECTS, GRANTS, AND TEACHING CONTRIBUTIONS💡

Dr. Liu has secured significant funding from national and provincial sources, including the National Key Research and Development Program Project and the Guangdong Provincial Basic and Applied Basic Research Fund, among others. Dr. Liu teaches a range of subjects, including Medical Informatics, Bioinformatics, and Epidemiological Methods. Her courses prepare students for practical applications in computational biology and medical statistics.

OTHER NOTABLE ACHIEVEMENTS 🏆

  • Grants: Dr. Liu has secured several substantial research grants, including the National Key Research and Development Program Project on ischemic cerebrovascular disease and respiratory viruses, underscoring her expertise in multi-omics approaches.
  • Teaching: She is an active educator, teaching courses such as Fundamentals and Experiments in Medical Informatics, Python and Computational Biology, and Epidemiological Methods, shaping the next generation of bioinformatics and medical statistics experts.
  • Honors and Awards: Dr. Liu’s accolades include the Important Scientific Research Achievement Award at BGI-Shenzhen and recognition as a Shenzhen High-level Overseas Talent, highlighting her achievements and influence within the academic and research communities.

NOTABLE PUBLICATIONS 📑

"Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies" 

  • Authors: Wei, Y. , Zhen, J. , Hu, L. , Xiong, L. , Liu, S
  • Journal: Nature Communications
  • Year: 2024

"Efforts made, challenges faced, and recommendations provided by stakeholders involved in mpox prevention and control in China: a qualitative study" 

  • Authors: Zhang, W. , Qi, X. , Han, B. , Meng, X. , Zou, H
  • Journal: Public Health
  • Year: 2024

"Genome-wide association study of maternal plasma metabolites during pregnancy" 

  • Authors: Liu, S. , Yao, J. , Lin, L. , Jin, X. , Liu, S.
  • Journal: Cell Genomics
  • Year: 2024

"Advances in using non-invasive prenatal testing to study genomics related to maternity" 

  • Authors: Jin, X. , Xu, X. , Zhou, A. , Wang, T. , Liu, H.
  • Journal: Cell Genomics
  • Year: 2024

"Utilizing non-invasive prenatal test sequencing data for human genetic investigation" 

  • Authors: Liu, S. , Liu, Y. , Gu, Y. , Jin, X. , Huang, S.
  • Journal: Cell Genomics
  • Year: 2024