Spyridon Theofilopoulos | Development Neurobiology | Best Researcher Award

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Prof. Spyridon Theofilopoulos | Development Neurobiology | Best Researcher Award

Deree-The American College of Greece | Greece

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EARLY ACADEMIC PURSUITS

Spyridon Theofilopoulos embarked on his academic journey with a Bachelor of Science degree in Biochemistry from Imperial College of Science, Technology and Medicine, London, U.K. Following this, he pursued his passion for developmental neurobiology, obtaining his Ph.D. from the same institution. His doctoral research, supervised by Professor Henry F. Bradford, focused on neurotrophic factors in neurotransmitter phenotype determination and neuroprotection in the developing human and rat brain.

PROFESSIONAL ENDEAVORS

Dr. Theofilopoulos has held various academic positions internationally, demonstrating his expertise and commitment to the field. Noteworthy roles include his tenure as a Forskare (Senior Researcher/Assistant Professor) at the Karolinska Institute, Stockholm, Sweden, and as a Sêr Cymru II Rising Star fellow and Associate Professor at Swansea University Medical School, Swansea, U.K. Currently, he serves as a Professor and Instructor at the Biomedical Sciences Department of Deree-The American College of Greece, Athens, Greece.

CONTRIBUTIONS AND RESEARCH FOCUS ON DEVELOPMENT NEUROBIOLOGY

Dr. Theofilopoulos has made significant contributions to the field of developmental neurobiology, particularly in the areas of neuroprotection and neurotransmitter phenotype determination. His collaborative research with Teva Pharmaceuticals during his Ph.D. led to the development of Rasagiline, a novel compound for the treatment of Parkinson’s disease. Moreover, his work at Swansea University resulted in the establishment of the spin-off company CholesteniX Ltd, aiming to develop specific cholesterol metabolites for Amyotrophic Lateral Sclerosis therapy.

IMPACT AND INFLUENCE

Theofilopoulos's research has not only contributed to scientific advancements but has also garnered recognition and accolades. He has been invited as a speaker to numerous conferences and meetings, highlighting the impact of his work in the scientific community. Furthermore, his efforts were acknowledged with awards such as the "Outstanding Research and Innovation collaboration in Medicine, Health and Life Sciences" award in 2022.

ACADEMIC CITATIONS

Dr. Theofilopoulos's work has been cited extensively, indicating its relevance and impact in the scientific community. His publications have appeared in reputable journals, and he has served as a reviewer for various scientific publications, including Scientific Reports, eLife, and Frontiers in Cell and Developmental Biology.

LEGACY AND FUTURE CONTRIBUTIONS

Dr. Theofilopoulos's legacy lies in his dedication to advancing knowledge in developmental neurobiology and his commitment to mentoring the next generation of scientists. His research funding awards underscore the importance of his work and pave the way for future discoveries in the field. As he continues his academic journey, his contributions are expected to further shape the landscape of neuroscience research.

NOTABLE PUBLICATIONS

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features 2021(10)

Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development 2024

Mining for oxysterols in cyp7b1−/− mouse brain and plasma: Relevance to spastic paraplegia type 5 2019(13)

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo 2019(24)

Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma 2019(29)

 

Xiaohu Ren | Metabolic disorders and their genetic basis | Best Researcher Award

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Prof Dr. Xiaohu Ren | Metabolic disorders and their genetic basis | Best Researcher Award

Shenzhen Center for Disease Control and Prevention | China

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EARLY ACADEMIC PURSUITS:

Dr. Xiaohu Ren commenced his academic journey with a Bachelor of Science in Biological Sciences from Shenzhen University (2005-2009), followed by a Master of Science in Biochemistry and Molecular Biology (2009-2012) from the same institution. Subsequently, he pursued a Ph.D. in Health Toxicology at Southern Medical University (2012-2015), where he laid the foundation for his research expertise in the field of toxicology.

PROFESSIONAL ENDEAVORS:

Since 2015, Dr. Ren has served as an Associate Chief Physician and Assistant Researcher at the Modern Toxicology Laboratory, Shenzhen Center for Disease Control and Prevention (CDC). Prior to this, he contributed as a Postdoctoral Researcher at the Shenzhen CDC from 2015 to 2017. These roles have provided him with ample opportunities to delve into the intricacies of environmental pollutants and occupational toxicants research.

CONTRIBUTIONS AND RESEARCH FOCUS ON METABOLIC DISORDERS AND THEIR GENETIC BASIS:

Dr. Ren's research endeavors have predominantly revolved around unraveling the molecular mechanisms underlying the damage inflicted on the human body by toxic substances. His expertise spans various analytical techniques, including proteomics, untargeted lipidomics, metabolomics, and cell phenotyping. Noteworthy among his contributions are the establishment of several toxicological testing and analysis methodologies, which have significantly advanced the field.

IMPACT AND INFLUENCE:

As an active member of numerous toxicological societies and committees in China, Dr. Ren has played a pivotal role in shaping the discourse surrounding toxicology research in the country. His work has garnered attention both nationally and internationally, contributing to the broader understanding of environmental health and toxicology.

ACADEMIC CITATIONS:

Dr. Ren's research findings have been cited extensively in the academic community, attesting to the significance and relevance of his contributions to the field. His publications have enriched the scientific literature on DNA repair pathways affected by environmental toxicants and carcinogenesis, shedding light on critical aspects of human health and disease.

LEGACY AND FUTURE CONTRIBUTIONS:

With a solid foundation established through years of academic pursuit and professional engagement, Dr. Xiaohu Ren continues to be a driving force in toxicology research. His legacy encompasses a body of work that has not only advanced scientific knowledge but also contributed to the development of practical solutions for mitigating the adverse effects of environmental pollutants. Moving forward, Dr. Ren remains committed to furthering his research agenda, with a focus on addressing emerging challenges in the field and making lasting contributions to public health and environmental well-being.

Notable Publications

Co-exposure to parabens and triclosan and associations with cognitive impairment in an elderly population from Shenzhen, China 2023(2)

Long term exposure of saxitoxin induced cognitive deficits and YAP1 cytoplasmic retention 2023(2)

The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China 2023(4)

Association between human herpesvirus 6 (HHV-6) and cognitive function in the elderly population in Shenzhen, China 2022(3)