Yong Xu | Cartilage Tissue | Best Researcher Award

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Dr. Yong Xu | Cartilage Tissue | Best Researcher Award

Tongji University | China

Author Profile

Scopus

✨ XU YONG: A PIONEER IN TUMOR TREATMENT AND TISSUE REPAIR ✨

🎓 EARLY ACADEMIC PURSUITS

Xu Yong was born on May 29, 1991, in Fuzhou, Jiangxi, and pursued a career in medicine from an early age. He embarked on his academic journey at Tongji University School of Medicine, where he obtained his Bachelor of Clinical Medicine (2010-2015). With a keen interest in thoracic surgery and tissue engineering, he continued his education at Shanghai Pulmonary Hospital, earning a Master's Degree in Thoracic Surgery (2015-2018). His academic dedication led him to pursue a Ph.D. in Thoracic Surgery (2018-2021) at the same institution, where he developed expertise in tumor treatment and tissue repair.

🌟 PROFESSIONAL ENDEAVORS

Following his Ph.D., Xu Yong joined Shanghai Pulmonary Hospital as a Resident Physician (2021-2024), where he honed his clinical skills in thoracic surgery and tissue engineering. In August 2024, he transitioned to a research-focused role as a Special Associate Researcher at the Nuclear Industry 416 Hospital, Provincial Clinical Medical Research Center. His work in this position is instrumental in advancing innovative solutions for tracheal tissue engineering and regenerative medicine.

⚖️ CONTRIBUTIONS AND RESEARCH FOCUS ON CARTILAGE TISSUE

Xu Yong’s research primarily revolves around tissue engineering for cartilage regeneration, with a strong emphasis on functional tracheal reconstruction. His groundbreaking work introduced the "ring strategy", which enables the construction of bionic tracheal tissue with an alternating cartilage ring-connective tissue ring arrangement. This strategy successfully demonstrated long-term functional reconstruction of long-segment tracheal defects in rabbit models.

⚛️ MAJOR RESEARCH PROJECTS

Xu Yong has been the Principal Investigator (PI) in multiple prestigious projects, including:

  • Shanghai Science and Technology Rising Star Project (2024-2027): Focused on high-bionic tracheal tissue engineering (400,000 RMB).
  • Youth Talent Support Project (2023-2025): Dedicated to tracheal tissue engineering (300,000 RMB).
  • National Natural Science Foundation of China (2024-2026): Developing simulated tracheal tissue for large animal models (300,000 RMB).
  • Shanghai Natural Science Foundation (2022-2025): Advancing the construction of bioengineered trachea (200,000 RMB).

Additionally, he is a key participant in a major project funded by the National Natural Science Foundation of China (2,150,000 RMB), focusing on the precise matching of multiple cell types for bionic construction of long-segment trachea.

✨ IMPACT AND INFLUENCE

Xu Yong’s contributions have significantly influenced the field of tissue engineering and regenerative medicine, particularly in tracheal defect repair. His innovative biomimetic tracheal tissue construction has paved the way for improved clinical applications in treating long-segment tracheal defects. His research bridges the gap between basic science and clinical translation, offering promising therapeutic solutions for thoracic surgery.

🏆 ACADEMIC CITATIONS AND PUBLICATIONS

Xu Yong has an impressive publication record, contributing to over 30 SCI papers with a cumulative impact factor exceeding 300. His key achievements include:

  • 20 papers as first/co-first author
  • 14 papers as corresponding/co-corresponding author
  • 15 papers with an impact factor greater than 10
  • Highest single impact factor: 27.4

Notable journals where his research has been published:

  • Advanced Materials (ADV MATER)
  • Advanced Functional Materials (Adv. Funct. Mater.)
  • Advanced Science (Adv Sci.)
  • Composites Part B: Engineering (COMPOS PART B-ENG)
  • International Journal of Bioprinting (INT J BIOPRINTING)

Additionally, he holds over 10 patents related to tissue engineering and regenerative medicine.

🎬 LEGACY AND FUTURE CONTRIBUTIONS

Xu Yong’s pioneering efforts in tracheal tissue engineering and tumor treatment have established a new benchmark in the field. His ring strategy has set the foundation for future research in biomimetic tracheal reconstruction. Moving forward, he aims to:

  • Advance clinical translation of biomimetic tracheal tissue into human trials.
  • Explore novel biomaterials and tissue engineering scaffolds.
  • Collaborate on interdisciplinary projects integrating AI-driven biomaterial development.

His contributions will continue to shape the future of thoracic surgery, offering lifesaving solutions for patients with severe tracheal defects.

✨ CONCLUSION

Xu Yong is a trailblazer in regenerative medicine and thoracic surgery, whose dedication to tissue engineering and tracheal reconstruction has the potential to revolutionize the field. With a solid foundation in research, clinical expertise, and a vision for innovation, he is poised to make lasting contributions to modern medicine.

📑 NOTABLE PUBLICATIONS 

"Cartilage structure-inspired nanofiber-hydrogel composite with robust proliferation and stable chondral lineage-specific differentiation function to orchestrate cartilage regeneration for artificial tracheal construction" 

  • Authors: Y., Li, Yaqiang , X., Xun, Xiaowei , L., Duan, Liang , Y., Xu, Yong , H., Xia, Huitang
  • Journal: Bioactive Materials
  • Year: 2025

"Polydopamine-loaded microneedles for sequential tumor ablation and osteochondral regeneration" 

  • Authors: B., Lin, Bin , Y., Xu, Yong , B., Liang, Bing
  • Journal: Materials Letters
  • Year: 2025

"Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration" 

  • Authors: P., Wang, Pengli , E., Gao, Erji , T., Wang, Tao , C., Yang, Chen , L., Duan, Liang
  • Journal: Journal of Nanobiotechnology
  • Year: 2024

"3D printing of Ceffe-infused scaffolds for tailored nipple-like cartilage development" 

  • Authors: J., Ding, Jinghao , C., Wei, Chuanzhi , Y., Xu, Yong , W., Dai, Wufei , R., Chen, Ru
  • Journal: BMC Biotechnology
  • Year: 2024

"Injectable and self-healing sulfated hyaluronic acid/gelatin hydrogel as dual drug delivery system for circumferential tracheal repair" 

  • Authors: Y., Yang, Yayan , X., Zhu, Xinsheng , X., Liu, Xuezhe , N., Song, Nan , Q., Feng, Qian
  • Journal: International Journal of Biological Macromolecules
  • Year: 2024

Chaohua Deng | Osteoarthritis | Best Researcher Award

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Dr. Chaohua Deng | Osteoarthritis | Best Researcher Award

Huazhong University of Science and Technology | China

Author Profile

Scopus

👨‍⚕️ BIOGRAPHY OF CHAOHUA DENG

🏛 EARLY ACADEMIC PURSUITS

Chaohua Deng was born on April 12, 1988. He embarked on his academic journey in clinical medicine at Wuhan University, where he earned his Bachelor's degree in Clinical Medicine in 2011. Demonstrating a keen interest in advancing his expertise, he pursued a Master’s degree in Clinical Medicine at Wuhan University, completing it in 2013. Seeking further specialization, he continued his studies abroad and obtained a Ph.D. in Life and Health Sciences from the University of Lorraine, France, in 2017. His doctoral research contributed significantly to his understanding of ophthalmology and related biomedical sciences.

👨‍⚕️ PROFESSIONAL ENDEAVORS

Deng’s professional career has been dedicated to clinical ophthalmology, with progressive advancements in his roles at Tongji Hospital, Huazhong University of Science and Technology:

  • Physician (2017-2019): Started as a physician in the Department of Ophthalmology, where he gained hands-on experience in diagnosing and treating ophthalmic conditions.
  • Attending Physician (2019-Present): Promoted to Attending Physician, Deng played a more active role in patient care, surgical interventions, and medical research.
  • Associate Chief Physician (2022-Present): Achieved a senior position where he leads research projects and continues to contribute to clinical advancements in ophthalmology.

🏥 CONTRIBUTIONS AND RESEARCH FOCUS ON OSTEOARTHRITIS

Deng's research primarily focuses on the molecular mechanisms underlying eye diseases and innovative treatment approaches. His National Natural Science Foundation of China (NSFC) projects reflect his commitment to advancing ophthalmic science:

  • Irisin Activation in Trabecular Cells (Ongoing, Participant, 2023-2026): Investigating the Integrin αVβ5-Rac1 signaling pathway in trabecular meshwork cells to enhance aqueous outflow, a crucial area for glaucoma treatment.
  • Vitamin K and Trabecular Meshwork Aqueous Outflow (Completed, Principal Investigator, 2022-2024): Explored how Vitamin K upregulates MGP expression in trabecular cells, which can improve fluid dynamics in the eye.
  • Single-Cell Transcriptome Analysis on Retinal Injury (Completed, Participant, 2021-2024): Studied the role of Sideroflexin3 in retinal recovery through single-cell transcriptomics.

🌍 IMPACT AND INFLUENCE

Deng has made valuable contributions to the ophthalmology community through his clinical expertise and research. His findings have potential implications for glaucoma treatment, retinal injury recovery, and overall eye health. His involvement in international academic conferences has allowed him to share insights and collaborate with global experts.

📚 ACADEMIC CITES AND AWARDS

  • Patent Contribution (2018): Co-author of a patent on mineralocorticoid receptor antagonists for osteoarthritis treatment (WIPO PCT/EP2017/068785).
  • International Conference Participation (2016-2017): Attended the OARSI World Congress on Osteoarthritis in Amsterdam, Netherlands, presenting his work to an esteemed audience of researchers.

🏆 LEGACY AND FUTURE CONTRIBUTIONS

Chaohua Deng’s legacy is built upon his clinical excellence, research innovations, and contributions to ophthalmology. As an Associate Chief Physician, he is well-positioned to mentor young professionals, drive future research in ocular disease mechanisms, and pioneer new treatment modalities for eye conditions. His work continues to influence the field, with ongoing research that aims to enhance vision care and therapeutic strategies for ophthalmic diseases.

📑 NOTABLE PUBLICATIONS

"Irisin attenuates acute glaucoma-induced neuroinflammation by activating microglia-integrin αVβ5/AMPK and promoting autophagy " 

  • Authors: Q., Zhang, Qiuxiang , S., Xiang, Sifei , X., Chen, Xi , C., Deng, Chaohua , J., Wang, Junming
  • Journal: International Immunopharmacology
  • Year: 2024

"Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte " 

  • Authors: C., Deng, Chaohua , N., Presle, Nathalie , A., Pizard, Anne , A., Bianchi, Arnaud , H., Kempf, Hervé
  • Journal: International Journal of Molecular Sciences
  • Year: 2024